NCT05558072

Testicular Torsion

Is There a Toll-like 4 Receptor Relationship in Patients With Testicular Torsion?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Hisar Intercontinental Hospital · Academic / Other
• Sex: Male
• Age: 0 Days – 16 Years
• Healthy volunteers: Accepted

Summary

Background: Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion. Recently, with the discovery of "Toll-Like Receptors" (TLRs), new horizons have been opened in the field of innate immune system-related diseases. Objective: To mediate the relationship between testicular torsion and TLR4 receptors. Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.

Detailed description

Analysis of 32 newborns and 32 adolescents between the ages of 14 and 16 (mean age was 15.17 ± 0.98) testicular tissue lysate using Toll-Like Receptor antibody 4 (TLR4) ELISA (Enzyme-Linked ImmunoSorbent Assay). Toll-like receptor 4 is a transmembrane protein that in humans is encoded by the TLR4 gene. Its activation leads to the production of inflammatory cytokines.

Conditions

• Testicular Torsion and TLR 4 Was Investigated

Interventions

Type	Name	Description
GENETIC	Toll-like receptor 4	Toll-like receptor 4

Timeline

• Start date: 2012-01-01
• Primary completion: 2021-12-30
• Completion: 2022-04-30
• First posted: 2022-09-28
• Last updated: 2022-09-28