NCT05558020

Feasibility of Constant Work Rate Testing to Detect Exercise-induced Laryngeal Obstruction

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

TITLE Feasibility of constant work rate testing to detect exercise-induced laryngeal obstruction DESIGN Prospective observational pilot study AIMS To investigate if constant work rate testing at different work rates will sufficiently induce detectable exercise-induced laryngeal obstruction (EILO) using CLE. POPULATION Adult patients with EILO DURATION 01.09.2022 - 30.06.2023

Conditions

• Exercise-induced Laryngeal Obstruction (EILO)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Continuous laryngoscopy during exercise (CLE), incremental exercise protocol	The incremental work rate exercise test will be performed using a cycle-ergometer. The exercise protocol is initiated by a five-minute warm-up at 50 Watts (W). Subsequently, they will complete a stepwise protocol, which will begin at 100 W and increase by 2 W every 6th second, until exhaustion or until the patient is unable to continue exercise, for any reason.
DIAGNOSTIC_TEST	Continuous laryngoscopy during exercise (CLE), continuous work rate protocol	Within two weeks the participants will perform an additional CLE-test at various intensities. The new exercise protocol is designed to induce EILO at different exercise intensities. Using the participants' individually calculated exercise capacity, three different workloads (70 %, 80 % and 90 %) will be calculated. The exercise protocol will be initiated with a five-minute warm-up at 50 W, then the workload will increase to the watt equivalent to 70 % of the participant's maximal exercise capacity. This workload will be fixed for ten minutes and only terminated if the participant feels the need to stop due to exhaustion or breathing difficulties. Next, the participant will have a five-minute resting phase with a set workload of 50 W. This protocol will be repeated at a workload equivalent to 80 % and 90 %

Timeline

• Start date: 2022-12-05
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2022-09-28
• Last updated: 2023-08-16

Locations

1 site across 1 country: Denmark