NCT05555680

Effect of Hyperandrogenism on IVF Outcomes in PCOS Patients

Effect of Hyperandrogenism on IVF Success Rates in PCOS Patients

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 32 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: 18 Years – 39 Years
• Healthy volunteers: —

Summary

Ovulatory dysfunction affects 18 to 25% of infertile women, the most common identifiable condition is polycystic ovarian syndrome (PCOS). The most frequent symptoms of PCOS are oligo-anovulation, hyperandrogenism and polycystic ovary appearance. Hyperandrogenism is the main contributor that affects oocyte and embryo quality and decreases the success rates in PCOS patients undergoing IVF treatments. The aim of this study is to determine the effect of hyperandrogenism as an independent factor on IVF success rates and oocyte/embryo quality in PCOS patients undergoing IVF.

Detailed description

Despite that PCOS patients obtain a higher yield of oocytes retrieved in IVF treatments, they often have lower fertilization, cleavage and implantation rates and a higher rate of miscarriage, which can be attributed to a poor quality of retrieved oocytes and the resulting embryos. Multiple studies compared IVF outcomes in PCOS patients to control groups and found that PCOS might negatively affect oocyte maturation rate, fertilization rate in conventional IVF and miscarriage rate. Hence, it seems that PCOS might be associated with poor outcomes in IVF cycles when compared to non-PCOS patients.

Conditions

• PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

Interventions

Type	Name	Description
OTHER	Ferriman-Gallwey Score	The Ferriman-Gallwey score is used to evaluate hirsutism. The examiner scores the subjects on a scale of 0-4 for terminal hair growth on eleven different body areas according to the Ferriman-Gallwey scoring system. A Ferriman-Gallwey score of 8 or more was considered diagnostic of hirsutism

Timeline

• Start date: 2022-01-21
• Primary completion: 2025-01-29
• Completion: 2025-01-29
• First posted: 2022-09-27
• Last updated: 2025-12-09

Locations

1 site across 1 country: Canada