NCT05554653

Influence of Leucine Enriched Amino Acids on Myofibrillar and Collagen Protein Synthesis

Influence of Leucine Enriched Amino Acids on Myofibrillar and Collagen Protein Synthesis in Human Skeletal Muscle

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Daniel Moore · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The primary objective will be to determine the effect of leucine-enriched essential amino acids (LEAA) compared to carbohydrate placebo on dietary incorporation of \[D5\] Phenylalanine \& \[D5\] Glycine into the three skeletal muscle protein pools (myofibrillar, sarcoplasmic and collagen), both following resistance exercise and at rest, with the two tracers provided as a 'intrinsically labeled' bolus. Other outcomes will relate to molecular regulation of protein synthesis.

Conditions

• Interventional

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Leucine enriched amino acids	Leucine enriched essential amino acids (4g total, of which 1.6g are leucine). 20g carbohydrate, 2g of protein free drink powder, and 5g of Splenda.
DIETARY_SUPPLEMENT	Carbohydrate Placebo	iso-caloric placebo (4g maltodextrin). 20g carbohydrate, 2g of protein free drink powder, and 5g of Splenda.

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-10-03
• Completion: 2024-08-01
• First posted: 2022-09-26
• Last updated: 2023-11-13

Locations

1 site across 1 country: Canada