NCT05554588

Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI

A Randomized Trial of Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction Patients With High Thrombus Burden

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,500 (estimated)
• Sponsor: China-Japan Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus thrombolysis or manual aspiration thrombectomy during primary percutaneous coronary intervention(PPCI).

Detailed description

The hypothesis for ATTRACTIVE trial is that the intrathrombus thrombolysis with microcatheter or pierced balloon compared to manual aspiration thrombectomy will reduce the incidence of major adverse cardiovascular events(MACEs), including cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or heart failure rehospitalization, stent thrombosis and target-vessel revascularization at 1 year in STEMI patients with HTB undergoing PPCI.

Conditions

• Acute Coronary Syndrome
• ST Elevation Myocardial Infarction
• Percutaneous Coronary Intervention

Interventions

Type	Name	Description
PROCEDURE	Intrathrombus Thrombolysis During Primary PCI	Intrathrombus Thrombolysis During Primary PCI
PROCEDURE	Aspiration Thrombectomy During Primary PCI	Aspiration Thrombectomy During Primary PCI

Timeline

• Start date: 2022-09-13
• Primary completion: 2026-03-01
• Completion: 2026-09-01
• First posted: 2022-09-26
• Last updated: 2022-09-26

Locations

1 site across 1 country: China