Trials / Completed
CompletedNCT05548998
Effect of Low Flow Anesthetics on Neurocognitive Decline in the Elderly
Effect of Low Fresh Gas Flow Volatile Anesthetics on Postoperative Neurocognitive Function in Elderly Patients
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 230 (actual)
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to investigate the effect of inhaled anesthetics with a low fresh gas flow on cognitive function of elderly patients undergoing elective surgery
Detailed description
Geriatric patients scheduled to undergo surgery were tested with Mini Mental State Examination (MMSE) in the preoperative visit. MMSE was repeated postoperatively at the 6th hour, the 1st, 3rd, and 7th day. Visual analogue scale (VAS) test was performed simultaneously on the postoperative 6th hour, the 1st, 3rd, and 7th day. Two cohorts were created according to the amount of fresh gas flow (low flow vs high flow) in the maintenance phase of the inhalational anesthetic. MMSE scores were compared between cohorts and baseline. VAS scores were compared between cohorts.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | General anesthesia with low fresh gas flow | General anesthesia with a fresh gas flow lower than 1L/min for the maintenance phase of anesthesia |
| OTHER | General anesthesia with high fresh gas flow | General anesthesia with a fresh gas flow equal to or higher than 1L/min for the maintenance phase of anesthesia |
| DIAGNOSTIC_TEST | Mini mental state examination | 6 category and 30-point test to inquire patient's cognitive function |
| DIAGNOSTIC_TEST | Visual Analogue Scale | The patient's self-reported pain intensity according to a visual scale between 0 and 100 |
Timeline
- Start date
- 2019-05-01
- Primary completion
- 2019-11-01
- Completion
- 2019-11-01
- First posted
- 2022-09-22
- Last updated
- 2022-09-22
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT05548998. Inclusion in this directory is not an endorsement.