NCT05548933

Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia

Effects of Nonsurgical Periodontal Therapy on Biomarkers in Serum and Gingival Crevicular Fluid in Severe Periodontitis (Stage III/IV) and Hyperlipidemia:A Cohort Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 64 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.

Detailed description

This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.MCP-1, IL-8, oxLDL, TNF-α will be tested for concentration using ELISA.

Conditions

• Periodontitis Chronic Generalized Severe
• Hyperlipidemia
• Gingival Crevicular Fluid
• Serum
• Biomarkers
• Non-surgical Periodontal Therapy

Interventions

Type	Name	Description
PROCEDURE	non-surgical periodontal therapy	supragingival scaling,subgingival scaling

Timeline

• Start date: 2022-09-20
• Primary completion: 2023-11-01
• Completion: 2023-11-01
• First posted: 2022-09-22
• Last updated: 2022-09-22

Locations

1 site across 1 country: China