NCT05547971

Development of Intelligent Model for Radioactive Brain Damage of Nasopharyngeal Carcinoma Based on Radio-metabolomics

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: Xiangya Hospital of Central South University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: —

Summary

This project focuses on the early prediction and diagnosis of radiation-induced brain injury in nasopharyngeal carcinoma patients. Based on the big data of imaging and serum metabonomics samples, combined with the machine learning analysis method， dynamic evolution mode of radio-metabolomics characteristics was analyzed . The potential internal relationship between brain structure and serum metabolic changes was explored, and the individualized prediction model was constructed to screen out the high-risk patients with brain injury after tumor radiotherapy, so as to provide reference for the diagnosis of radiation-induced brain injury caused by tumor. radiotherapy Intelligent diagnosis provides a new theoretical and practical basis.

Detailed description

Research Process 1. The MRI based cohort data set of nasopharyngeal carcinoma was established, and the data of multiple follow-up time points before and after radiotherapy (including initial diagnosis, 6 months, 12 months and 24 months after radiotherapy) were standardized to obtain the longitudinal data set; 2. Region of interest (ROI): it mainly delineates the bilateral temporal lobe, brain stem and other brain regions, and extracts the corresponding image features in ROI; 3. Feature selection: using the strategy of radiomics combined with Artificial Neural Network to reduce the dimension of high-dimensional image features, the key features are selected and used for the subsequent construction of classification and prediction model; 4. Extracting key features: using vertical axis data analysis method and logistic regression to establish dynamic prediction model.

Conditions

• Nasopharyngeal Carcinoma

Interventions

Type	Name	Description
RADIATION	intensity-modulated radiation therapy	The patients got intensity-modulated radiation therapy during observation

Timeline

• Start date: 2022-09-01
• Primary completion: 2023-06-01
• Completion: 2023-06-01
• First posted: 2022-09-21
• Last updated: 2022-09-21

Locations

1 site across 1 country: China