NCT05547880

CNS Correlates of Extended Sleep Restriction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 13 (actual)
• Sponsor: Walter Reed Army Institute of Research (WRAIR) · Federal
• Sex: All
• Age: 18 Years – 39 Years
• Healthy volunteers: Accepted

Summary

Chronic sleep restriction is ubiquitous in both the general population and the military. The deleterious effects of sleep loss on human alertness and cognitive performance have been documented in numerous studies dating back to the nineteenth century. Over the past decade, evidence has emerged indicating that chronic sleep restriction may also precipitate deleterious, long lasting neuropathological changes in the brain. The purpose of this study is to determine neuropathological effects of sleep restriction and identify physiological mechanisms that correlate with sleep loss-induced performance impairment.

Conditions

• Sleep Restriction

Interventions

Type	Name	Description
DRUG	[11C]ER176	Brain PET with \[11C\]ER176. \[11C\]ER176 is a PET ligand that images TSPO.

Timeline

• Start date: 2023-05-23
• Primary completion: 2025-03-15
• Completion: 2025-03-15
• First posted: 2022-09-21
• Last updated: 2025-05-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study