NCT05544110

Precise Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

Study on the Effect and Mechanism of Individualized and Precise Location Transcranial Magnetic Stimulation Based on Magnetic Resonance Imaging on Post-traumatic Stress Disorder

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the efficacy and safety of repetitive transcranial magnetic stimulation under precise localization for post-traumatic stress disorder

Detailed description

Participants who meet the entry conditions and sign the informed consent will be divided into two groups. The stimulation target of each participant will be determined according to MRI. The test group will receive active transcranial magnetic stimulation for 10 consecutive days, and the control group will receive sham stimulation. Symptom severity is assessed by scales and audio and video recordings at baseline, during treatment period and follow-up.Blood samples will also be collected from patients prior to treatment and will be analyzed histologically to explore differences in response to the intervention and biological mechanisms in different subgroups of patients.

Conditions

• PTSD

Interventions

Type	Name	Description
DEVICE	Active transcranial magnetic stimulation	The coil parallel to the scalp is placed on the target for real and effective stimulation.
DEVICE	Sham transcranial magnetic stimulation	The coil is placed perpendicular to the scalp above the target for ineffective stimulation.

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-12-30
• Completion: 2025-06-30
• First posted: 2022-09-16
• Last updated: 2024-01-11

Locations

1 site across 1 country: China