NCT05543525

Myocardial Mechanics in Athlete's Heart

Advanced Myocardial Deformation Echocardiography for the Athlete's Heart Evaluation: Functional and Mechanistic Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 191 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy. This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.

Detailed description

Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS \<17.5%.

Conditions

• Athlete Heart

Interventions

Type	Name	Description
OTHER	Echocardiography	Transthoracic echocardiography
OTHER	Cardiopulmonary exercise testing	Cardiopulmonary exercise testing

Timeline

• Start date: 2021-07-01
• Primary completion: 2022-01-01
• Completion: 2022-01-01
• First posted: 2022-09-16
• Last updated: 2023-08-30

Locations

1 site across 1 country: France