NCT05541601

Prospective Cohort for Early Detection of Liver Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

This study aims to recruit 3000 people with liver cirrhosis into a Prospective cohort for early detection of Liver cancer - the Pearl cohort. The study team believe that using a combination of novel tests may improve the detection of early Hepatocellular Carcinoma (HCC).

Detailed description

During a four-year follow-up period, around 100 Pearl patients are expected to be diagnosed with HCC. Blood, urine, clinical and imaging data will be collected over the follow up period. The samples will be used to identify a range of tests (including genetic, protein and other biomarkers), which along with the clinical data will hopefully identify those most at risk of developing HCC, and to identify HCC at the earliest possible time points.

Conditions

• Cirrhosis
• Hepatocellular Carcinoma

Interventions

Type	Name	Description
OTHER	Blood and Urine samples	The samples will be used to identify a range of tests (including genetic, protein and other biomarkers), which along with the clinical data will hopefully identify those most at risk of developing HCC, and to identify HCC at the earliest possible time points.

Timeline

• Start date: 2022-02-23
• Primary completion: 2037-07-01
• Completion: 2037-07-01
• First posted: 2022-09-15
• Last updated: 2022-09-15

Locations

1 site across 1 country: United Kingdom