NCT05540561

Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse

Biological Alterations of Laughing Gas Outcomes in Neurology

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 356 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 14 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord. One thus frequently observes patients presenting disorders of walking or paresthesias, of more or less resolving evolution being able to go until the need for using a wheelchair and more recently cases of thrombosis were reported Serum or urine N2O assays are rarely performed routinely, because they do not allow to ensure a real exposure due to the very short half-life of this gas in the body. Thus, other biological monitoring markers are mentioned in the literature, such as vitamin B12 or homocysteine. Unfortunately, there are still no recommendations for biological monitoring of nitrous oxide consumption. Moreover, underlying mechanisms leading to clinical outcomes remains misunderstood.

Conditions

• Nitrous Oxide Abuse

Interventions

Type	Name	Description
OTHER	blood collection	Biological analyses in the framework of care with conservation of blood samples

Timeline

• Start date: 2023-01-30
• Primary completion: 2025-01-30
• Completion: 2025-01-30
• First posted: 2022-09-14
• Last updated: 2024-10-26

Locations

8 sites across 1 country: France