Trials / Enrolling By Invitation
Enrolling By InvitationNCT05539378
Exploring the Link Between Sleep and Brain Clearance
Biomarkers of Brain Clearance During Sleep
- Status
- Enrolling By Invitation
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- University Children's Hospital, Zurich · Academic / Other
- Sex
- All
- Age
- 50 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to assess the link between sleep and the clearance of waste products from the brain. This will be assessed in a group of healthy older adults.
Detailed description
First, the investigators want to assess the relationship between sleep parameters and markers for brain clearance, assessed with MRI and blood samples. Second, the investigators want to probe whether associations can be influenced by modulation of sleep parameters by means of auditory stimulation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Auditory Stimulation | enhancement of sleep slow wave activity through acoustic stimulation |
| BEHAVIORAL | Sham (no stimulation) | Playing no tones during sleep but still recording brain activity |
Timeline
- Start date
- 2023-06-29
- Primary completion
- 2026-12-01
- Completion
- 2027-06-01
- First posted
- 2022-09-14
- Last updated
- 2024-12-09
Locations
1 site across 1 country: Switzerland
Source: ClinicalTrials.gov record NCT05539378. Inclusion in this directory is not an endorsement.