NCT05538338

Platelet Rich Plasma for Insufficient Endometrium

Intrauterine Platelet Rich Plasma (PRP) Infusion for Endometrial Insufficiency: A Prospective, Double-Blind, Placebo-Controlled Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (estimated)
• Sponsor: Reproductive Medicine Associates of New Jersey · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

To determine the effectiveness of an intrauterine PRP infusion on endometrial thickness and in vitro fertilization (IVF) outcomes in a population of infertile women with a history of unresponsive thin endometrium.

Detailed description

Patients with a history of thin endometrium will be randomized to either an intrauterine infusion of PRP vs. a placebo infusion of normal saline. This is a double-blind, placebo controlled prospective RCT. Patients will then proceed with a frozen embryo transfer of a single euploid embryo per routine.

Conditions

• Infertility of Uterine Origin

Interventions

Type	Name	Description
OTHER	Platelet Rich Plasma Intrauterine infusion	an intrauterine infusion of platelet rich plasma (PRP) will be administered to this group of participants
OTHER	Normal saline Intrauterine infusion	an intrauterine infusion of normal saline will be administered to this group of participants

Timeline

• Start date: 2022-10-15
• Primary completion: 2025-10-01
• Completion: 2025-12-01
• First posted: 2022-09-13
• Last updated: 2025-02-07

Locations

1 site across 1 country: United States