NCT05537675

Semi-automated Segmentation Methods of SSTR PET for Dosimetry Prediction

Semi-automated Segmentation Methods of SSTR PET for Dosimetry Prediction in Refractory Meningiomas Treated by SSTR-targeted Peptide Receptor Radionuclide Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Tumor dosimetry with somatostatin receptor-targeted peptide receptor radionuclide therapy (SSTR-targeted PRRT) by 177Lutetium-DOTATATE might contribute to improve follow-up and treatment response of refractory meningiomas. This study aims to evaluate Standard Uptake Value mean (SUVmean) as a tumoral absorbed dose predictive predictive factor and propose semi-automated segmentation method to determine metabolic tumor volume with pretherapeutic 68-Gallium-DOTATOC PET.

Conditions

• Refractory Meningioma

Interventions

Type	Name	Description
OTHER	To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax	Measure SUVmean (Standard Uptake Value) and SUVmax on PET exams

Timeline

• Start date: 2022-10-01
• Primary completion: 2022-11-06
• Completion: 2022-11-30
• First posted: 2022-09-13
• Last updated: 2023-11-30

Locations

1 site across 1 country: France