NCT05536362

Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery

Consequences of Co-Administration of Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Egymedicalpedia · Industry
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The Study Showed that combining clonidine and ketamine together can increase the likelihood of achieving a sufficient level of anaesthesia while minimizing post-operative discomfort and inflammation.

Detailed description

This study aimd to determine whether propofol infusion combined with clonidine and ketamine is more efficient in lowering the level of IL-8, preserving operation stability, and dropping post-operative pain and morphine intake. When paralleled to propofol alone, TIVA employing propofol infusion along with pre-operation clonidine and ketamine is effective at preserving hemodynamic stability, dropping post-operative pain, and dipping morphine intake. For this study, sixty contestants with ASA physical status I and II, ranging in age from 35 to 65, were scheduled for colon cancer operation lasting longer than 120 minutes. This study excluded participants with a history of heart, renal and liver cell failure, allergic reaction to studied drugs, and history of epilepsy, hemodynamic instability, chronic pain, or mental illness. Using a computer-generated randomization list, the patients were randomly allocated into two groups (30 patients each). The treated group(Group T),which got intravenous anaesthesia with TCI propofol mixed with clonidine and ketamine, the control group(Group C),which received intravenous anaesthesia with TCI propofol mixed with a placebo (NaCl 0.9%) .A third party was included in this study so neither the researchers nor the research subjects are aware of the intervention which the patients got.

Conditions

• Colon Cancer
• Post Operative Pain

Interventions

Type	Name	Description
DRUG	TCI Propofol Injection	To decrease postoperative pain after cancer colon surgery

Timeline

• Start date: 2021-02-01
• Primary completion: 2022-01-01
• Completion: 2022-02-28
• First posted: 2022-09-10
• Last updated: 2022-10-26

Locations

1 site across 1 country: Egypt