NCT05536323

Bolus Versus Continuous Remimazolam for Anesthetic Induction

Comparison of the Incidence of Hypotension in Bolus Versus Continuous Administration of Remimazolam During Anesthesia Induction

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (estimated)
• Sponsor: Kangbuk Samsung Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Remimazolam is a newly introduced intravenous anesthetic, with rapid onset and offset. Although it is known to cause less hemodynamic instability, the incidence hypotension is the one of the most frequent adverse events with its use. For anesthetic induction, remimazolam can be used either as bolus dose or as continuous infusion. This study is aimed to investigate the incidence of hypotension after anesthetic induction with bolus (0.14-0.33 mg/kg) or continuous (12 mg/kg/hr) remimazolam administration.

Conditions

• Hypotension on Induction

Interventions

Type	Name	Description
DRUG	Remimazolam bolus	Remimazolam bolus 0.14-0.33 mg/kg 0.25-0.33 mg/kg, \<40 years 0.19-0.25 mg/kg, 60-80 years 0.14-0.19 mg/kg, \>80 years
DRUG	Remimazolam continuous	Remimazolam 12 mg/kg/hr

Timeline

• Start date: 2023-07-01
• Primary completion: 2023-11-01
• Completion: 2023-12-01
• First posted: 2022-09-10
• Last updated: 2023-06-02