NCT05534906

The Detection of Small Early Liver Cancer With Natural History Follow up

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The SELINA study will recruit 200 patients with cirrhosis and small HCC and 50 patients with HCC but without cirrhosis (most of whom are expected to have FLD). Blood, urine and liver tissue samples (where available) will be collected for laboratory analysis. In a subgroup of patients (N=80, around 64 patients with HCC with liver cirrhosis and around 16 patients with HCC without liver cirrhosis), additional magnetic resonance liver imaging will be performed. The findings of the SELINA study aim to identify biomarkers that can be used to detect liver cancer at the earliest possible time, something we expect will increase the survival rate of HCC.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
OTHER	Blood & Urine Samples	Blood and urine samples will be collected to help identify biomarkers that can be used to detect liver cancer at the earliest possible time
OTHER	Imaging	MRI \& MRE Scans

Timeline

• Start date: 2022-05-23
• Primary completion: 2035-06-01
• Completion: 2035-06-01
• First posted: 2022-09-10
• Last updated: 2022-09-10

Locations

1 site across 1 country: United Kingdom