NCT05534425

Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.

Detailed description

This randomized controlled intervention trial (planned n=160) will test whether participation in the Generation Xchange (GenX) intergenerational mentoring program can reduces vulnerability to respiratory virus infections (COVID, influenzas, colds), increase antiviral immune activity (Type I interferon responses), and reduce inflammatory immune activity in older African-American women and men living in a socioeconomically disadvantaged urban community. Blood samples will also be collected to determine which biological factors are most important in protecting older African-Americans from respiratory virus infection, and which of those factors is affected by the GenX intervention.

Conditions

• Virus Infection, RNA

Interventions

Type	Name	Description
BEHAVIORAL	GenX intergenerational mentoring program	GenX trains older adults to collaborate with K-3rd grade teachers in mentoring high-need elementary school students in core reading and math skills.

Timeline

• Start date: 2022-09-26
• Primary completion: 2027-08-01
• Completion: 2027-08-01
• First posted: 2022-09-09
• Last updated: 2025-09-04

Locations

1 site across 1 country: United States