NCT05533580

Differential Effects of Remimazolam and Propofol on Dynamic Cerebral Autoregulation During General Anesthesia

Differential Effects of Remimazolam and Propofol on Dynamic Cerebral

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Second Affiliated Hospital of Nanchang University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Cerebral autoregulation (CA) is the property of the cerebral vascular bed to maintain cerebral perfusion in the presence of changes in blood pressure. In the case of anesthesia, altered cerebral autoregulation, including altered carbon dioxide and hemodilution, can impair physiological changes in the body and lead to poor postoperative prognosis. As a novel ultra-short-acting benzodiazepines drugs, remimazolam has been accepted for induction and maintenance of clinical anesthesia. Compared to the traditional benzodiazepines drugs, remimazolam combines the safety of midazolam with the effectiveness of propofol, and also has the advantages of acting quickly, short half-life, no injection pain, slight respiratory depression, independent of liver and kidney metabolism, long-term infusion without accumulation, and has a specific antagonist: flumazenil. Our study aimed to investigate the different effects of remimazolam and propofol on dynamic cerebral blood flow autoregulation function during general anesthesia.

Conditions

• General Anesthesia
• Laparoscopic Cholecystectomy
• Remimazolam
• Propofol
• Dynamic Cerebral Autoregulation

Interventions

Type	Name	Description
DRUG	Remimazolam	The experimental group was sedated with remimazolam.
DRUG	Propofol	The control group was sedated with propofol.

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-01-31
• Completion: 2023-01-31
• First posted: 2022-09-09
• Last updated: 2022-09-29

Locations

1 site across 1 country: China