NCT05532449

Dezoxide Suppresses Sufentanil-induced Cough

Low-dose Dezoxide Suppresses Sufentanil-induced Cough During Induction of General Anesthesia in Patients Undergoing Cardiac Surgery: a Prospective, Randomized, Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 176 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Dizocine (0.03 mg/kg) or saline followed by sufentanil 0.4ug/kg was administered, and induction was completed with 3 min of observation. Heart rate and mean arterial pressure (MAP) were recorded before induction of anesthesia, before and 1 min after intubation, and side effects during induction, such as vomiting, hypoxemia (SpO2 \<90%), or other expected effects. The number of coughs was recorded in both groups, and the severity of cough was defined as follows: mild, 1-2 coughs; moderate, 3-4 coughs; severe, 5 or more coughs.

Conditions

• Sufentanil-induced Cough

Interventions

Type	Name	Description
DRUG	Intravenous dizocine	Intravenous dizocine (0.03mg/kg diluted to 5 ml)

Timeline

• Start date: 2022-09-12
• Primary completion: 2022-09-12
• Completion: 2023-09-30
• First posted: 2022-09-08
• Last updated: 2022-09-08