NCT05530330

Markers of Platelet Activation foR Identification of Late Onset Sepsis in Preterm Infants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 268 (actual)
• Sponsor: University College Dublin · Academic / Other
• Sex: All
• Age: 34 Weeks
• Healthy volunteers: Not accepted

Summary

The PARENT study will examine platelet and endothelial associated proteins in preterm infants being investigated for late onset sepsis (LOS) to see if infants with fulminant sepsis can be prospectively identified using these markers

Detailed description

Infants who are less than 34 weeks corrected gestational age at time of birth will be enrolled prior to any late onset sepsis investigations. At point of clinical concern for the development of late onset sepsis a 0.5-1.3ml sodium citrate sample will be taken. A targeted proteomic analysis using mass spectroscopy and flow cytometry will be performed and compared with the clinical diagnosis of the infant to examine if this can be used prospectively to identify infants with late onset sepsis

Conditions

• Late-Onset Neonatal Sepsis
• Necrotising Enterocolitis
• Culture Negative Neonatal Sepsis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Platelet/Endothelial proteomics	Samples taken will undergo a targeted proteomic investigation examining platelet/endothelial markers and associated extracellular vesicles

Timeline

• Start date: 2022-09-02
• Primary completion: 2025-02-28
• Completion: 2025-06-27
• First posted: 2022-09-07
• Last updated: 2025-07-03

Locations

2 sites across 1 country: Ireland