NCT05529485

Quantification of Factors Influencing Endothelial Damage During Phacoemulsification

Research and Quantification of Factors Influencing Endothelial Damage During Phacoemulsification

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 121 (actual)
• Sponsor: Centre Hospitalier Régional Metz-Thionville · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to determine the principal factors that influence endothelial cell loss three month post cataract surgery. Methods: Multi center observational Cohort study, inclusion period from 12/01/2022 to 10/06/2022. One hundred and seventy-five eyes of hundred and four patients who have appointment for cataract surgical indication were included. The percentage of corneal endothelial cell loss was quantified using specular microscopy before and 3 months after the surgery. 14 variables (pre-operative and intra-operative) that could be associated to endothelial cell injury were selected. A bivariate analysis of relationship between these factors and endothelial cell loss at 3 months was performed by simple linear regression (Wilcoxon and Fischer tests). Multivariate analysis was performed by multiple linear regression in order to identify the factors independently related to endothelial cell loss.

Conditions

• Endothelial Cell Loss, Corneal
• Cataract
• Phacoemulsification

Interventions

Type	Name	Description
PROCEDURE	Cataract surgery by phacoemulsification	Cataract surgery by phacoemulsification

Timeline

• Start date: 2022-01-12
• Primary completion: 2022-08-01
• Completion: 2022-08-01
• First posted: 2022-09-07
• Last updated: 2022-09-10

Locations

1 site across 1 country: France