NCT05529108

Glycaemic Control Effect of BSG and Underlying Gut - Related Mechanism in Singapore Adults With Metabolic Syndrome

Impact of Brewer's Spent Grain (BSG) and Bio-transformed BSG Biscuits on Glycaemic Control and Gut Health in Singapore Adults With Metabolic Syndrome

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (estimated)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 35 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research project is to assess the glycaemic controlling effects of consuming BSG and bio-transformed BSG-containing biscuits and its underlying gut - related mechanism in adults with MetS using in-vivo setting.

Detailed description

This is a double-blind, randomised, parallel experiment, all subjects (38 adults in Singapore with MetS) will complete a 12-week intervention period. Subjects will be randomly assigned to consume their habitual diet with biscuit that either does not contain or contains autoclaved BSG or bio-transformed BSG for 12 weeks. Throughout the intervention, subjects will be assessed for glucose, insulin, lipid and amino acid responses, biomarkers of gut health, and as well as other markers of health.

Conditions

• Metabolic Syndrome
• Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	control biscuits	Consumption of plain biscuits everyday during intervention period.
DIETARY_SUPPLEMENT	autoclaved BSG-containing biscuits	Consumption of autoclaved BSG-containing biscuits everyday during intervention period.
DIETARY_SUPPLEMENT	bio-transformed BSG-containing biscuits	Consumption of bio-transformed BSG-containing biscuits everyday during intervention period.

Timeline

• Start date: 2022-10-28
• Primary completion: 2024-09-01
• Completion: 2024-09-01
• First posted: 2022-09-06
• Last updated: 2023-11-09

Locations

1 site across 1 country: Singapore