NCT05524792

Incidence of Diabetes After a COVID-19 Infection

Incidence of Diabetes After a COVID-19 Infection - Comparison of COVID-19 Patients, Non-infected Individuals, Historic Controls and Patients With Influenza

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 157,134 (actual)
• Sponsor: InGef - Institute for Applied Health Research Berlin GmbH · Industry
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Prospective observational study of the POINTED consortium to evaluate whether new diagnoses of diabetes mellitus, occur significantly more frequently in the post-acute phase of a laboratory-confirmed SARS-CoV-2 infection than in carefully matched control groups.

Detailed description

Long-term health sequelae of the coronavirus disease 2019 (COVID-19) are a major public health concern. There is evidence on new-onset hyperglycaemia and insulin resistance in patients without history of diabetes in the post-acute phase of COVID-19 (Long-Covid). This study is a longitudinal matched cohort study based on a total data pool of about 35 million SHI insured persons and investigates the incidence of a diabetes mellitus (differentiated into type 1, type 2 and other diabetes mellitus) diagnosis after confirmed SARS-Cov-2 infection compared to different control groups without SARS-Cov-2 infection. Individuals will be followed up from the date of diagnosis of SARS-Cov-2 infection, influenza diagnosis, or a randomly assigned index date for at least two quarters. To assess effects of Long-Covid on incidence of diabetes mellitus, follow-up begins with the second quarter after the quarter of the index date. The data analysis is carried out decentrally at the respective data holders of the POINTED consortium. Subsequently, the aggregated individual results are pooled.

Conditions

• COVID-19
• Diabetes Mellitus

Interventions

Type	Name	Description
OTHER	no interventional study	no interventional study

Timeline

• Start date: 2018-01-01
• Primary completion: 2021-09-30
• Completion: 2021-09-30
• First posted: 2022-09-01
• Last updated: 2024-03-25

Locations

1 site across 1 country: Germany