NCT05521919

Acute Plasma Abeta Responses to Stress

Effects of Acute Stress Exposure on Plasma Beta-amyloid Levels

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels in humans has yet to be examined. In this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.

Detailed description

Aim 1: determine whether acute exposure to stress (increasing sympathetic nervous system activation) increases plasma amyloid-beta-40 and amyloid-beta-42 in the five hours following exposure.

Conditions

• Stress Reaction
• Stress Physiology

Interventions

Type	Name	Description
BEHAVIORAL	Sympathetic Nervous System Activation	Participants will complete a task that increases sympathetic nervous system activation.
BEHAVIORAL	No-stress	Participants will complete a task that will not affect their sympathetic nervous system activity.

Timeline

• Start date: 2023-12-05
• Primary completion: 2024-12-10
• Completion: 2024-12-10
• First posted: 2022-08-30
• Last updated: 2025-12-10

Locations

1 site across 1 country: United States