Trials / Recruiting

RecruitingNCT05521451

Clinical Cohort Study - TRUST

Longterm Outcome and Predictors for Recurrence After Medical and Interventional Treatment of Arrhythmias At the University Heart Center Hamburg

Status: Recruiting
Phase: —
Study type: Observational
Enrollment: 5,000 (estimated)

Sponsor: Universitätsklinikum Hamburg-Eppendorf · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Accepted

Summary

The "Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg" (TRUST) study is an investor-initiated, single-center, prospective clinical cohort study including patients treated with cardiac arrhythmias or at high risk for cardiac arrhythmias. The design enables prospective, low-threshold, near complete inclusion of patients with arrhythmias treated at the UHZ. Collection of routine follow-up data, detailed procedural information and systematic biobanking will enable precise and robust phenotyping.

Detailed description

Arrhythmias such as atrial fibrillation, ventricular tachycardia, and sudden death remain major causes of morbidity and mortality. Their prevalence increases in our ageing populations. Modern therapy of these conditions, using a combination of drugs, devices, and interventions, can reduce the disease burden associated with cardiac arrhythmias. This prospective cohort study will collect detailed clinical, procedural, and outcome information in a large cohort of patients with arrhythmias seen in a tertiary care center. Clinical phenotyping will be enhanced by biosampling and analysis of circulating biomolecules. Digital capture of clinical information and of follow-up data is planned.

Conditions

Timeline

Start date: 2021-03-17
Primary completion: 2026-09-30
Completion: 2031-12-31
First posted: 2022-08-30
Last updated: 2025-03-30

Locations

1 site across 1 country: Germany

Source: ClinicalTrials.gov record NCT05521451. Inclusion in this directory is not an endorsement.