NCT05518747

Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.

Detailed description

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks . 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks. Clinical measurements and sampling will be performed at baseline, week 6 and week 12. Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters

Conditions

• Periodontitis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	In this group participants will receive probiotic supplements twice a day (morning and evening) for a period of 12 weeks.
DIETARY_SUPPLEMENT	Placebo	In this group participants will receive placebo twice a day (morning and evening) for at period of 12 weeks.

Timeline

• Start date: 2022-09-01
• Primary completion: 2023-07-01
• Completion: 2023-12-31
• First posted: 2022-08-29
• Last updated: 2022-11-02

Locations

1 site across 1 country: Denmark