NCT05517499

Efficacy of Dexamethasone in Treatment of Meconium Aspiration Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Services Institute of Medical Sciences, Pakistan · Other Government
• Sex: All
• Age: 24 Hours
• Healthy volunteers: Not accepted

Summary

Objective: To determine efficacy of dexamethasone in treatment of meconium aspiration syndrome. Study design: Randomized control trial. Place and duration: Services hospital, Neonatal unit, Lahore. During time span of 1st January to 30th June 2021. Material and methods Total 100 neonates were randomly divided in two groups. Group A (n=50) was treated with dexamethasone (Cases) and Group B (n=50) served as control. Dexamethasone was given in dose of 0.2mg/kg, 12 hourly for 7 days after confirmation of diagnosis. Infants present in clinical trial were evaluated by ventilation duration (invasive and non-invasive), oxygen therapy and hospital stay.

Detailed description

Data was analyzed in statistical analysis SPSS version 23. Means and Standard deviation were calculated for duration of non-invasive and invasive ventilation, hospital stay and oxygen therapy. Independent sample T test was applied and value \< 0.05 was taken as significant. Whereas frequency and percentages were taken for gender, gestation, mode of delivery and outcome of MAS and Chi-square test was applied, and p value \< 0.05 was taken as significant.

Conditions

• Efficacy, Self

Interventions

Type	Name	Description
DRUG	Dexamethasone	Randomized clinical trial

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-06-30
• Completion: 2021-06-30
• First posted: 2022-08-26
• Last updated: 2022-08-26

Locations

1 site across 1 country: Pakistan