NCT05515263

Snack Foods and Their Impact on the Immune Response Following Influenza Vaccination

Snack Foods and Their Impact on Immune Optimisation to the Influenza Vaccination: a Randomised Controlled Trial of a Vaccination Model of Immune Response

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (estimated)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 40 Years – 64 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the impact of replacing usual snacks with alternative snack foods on the immune response to influenza vaccination in a population of healthy, middle-aged adults.

Detailed description

Nutrition plays an important role in the immune system by providing energy and metabolites to support the function of immune cells, allowing them to initiate effective immune responses. Diet is therefore a modifiable factor in impacting immune function and is currently a topic of substantial interest in health research. Snack consumption has been shown to account for approximately 20-30% of daily energy intake in adults. Therefore, snack choices have the potential to influence dietary intake and quality, and therefore immune function, both positively and negatively. This study assesses the effect of replacing usual snacks with alternative snack foods on the immune response in a model of viral infection - the seasonal influenza vaccine containing four prevalent influenza virus strains for the 2022/23 or 2023/24 influenza season, as determined by the World Health Organization. This study is a parallel group, randomised controlled trial that will examine the replacement of usual snack foods with alternative snack foods on the immune response to seasonal influenza vaccination in humans, which will be assessed by measuring rates of seroconversion, and other immunological markers following vaccination. The intervention will be for 8 weeks, and influenza vaccination will be administered at 4-week midpoint. Participants will be followed up 3 months post-vaccination to assess incidence of upper respiratory symptoms.

Conditions

• Immune Response

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Intervention snack	To be eaten in replacement of usual snacks twice a day for 8 weeks.
DIETARY_SUPPLEMENT	Control snack	To be eaten in replacement of usual snacks twice a day for 8 weeks.

Timeline

• Start date: 2022-09-09
• Primary completion: 2024-06-01
• Completion: 2024-06-01
• First posted: 2022-08-25
• Last updated: 2023-07-27

Locations

1 site across 1 country: United Kingdom