NCT05514405

Effect of Remimazolam and Propofol on Postoperative Delirium

Effect of Remimazolam and Propofol on Postoperative Delirium in Elderly Patients Undergoing Hip and Knee Surgery

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 82 (estimated)
• Sponsor: Inje University · Academic / Other
• Sex: All
• Age: 65 Years – 100 Years
• Healthy volunteers: Accepted

Summary

Remimazolam is an ultra-short acting benzodiazepine agonist which is used widely for general anesthesia and sedation. Remimazolam has several advantages. Remimazolam is rapidly metabolized by tissue esterase that it does not accumulate even after infusion for long periods of time. The presence of reversal agents (flumazenil) is also advantageous. Also, hemodynamic stability compared to propofol gives clinicians preference to use for geriatric anesthesia. However, the study on the effect of remimazolam compared to propofol on postoperative delirium have not been carried out. The purpose of the study is to compare the incidence of postoperative delirium and recovery profile in elderly patients undergoing orthopedic surgery using either remimazolam or propofol.

Conditions

• Hip Fractures
• Knee Osteoarthritis
• Femur Fracture

Interventions

Type	Name	Description
DRUG	Remimazolam (Byfavo)	Remimazolam is continuously infused based on bispectral index (within 40-60).
DRUG	Propofol	Propofol is continuously infused based on bispectral index (within 40-60).

Timeline

• Start date: 2022-08-01
• Primary completion: 2026-08-31
• Completion: 2026-09-30
• First posted: 2022-08-24
• Last updated: 2026-03-27

Locations

1 site across 1 country: South Korea