NCT05510622

Uterine Microbiome in Recurrent Pregnancy Loss

Reproductive Tract Microbiome in Women With Recurrent Pregnancy Loss

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Mỹ Đức Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Accepted

Summary

The female genital tract microbiome may reflect female reproductive health and may be related to pregnancy outcomes. Disturbances in this microbiome may be associated with adverse reproductive outcomes. The investigators hypothesize that the endometrial and vaginal microbiome composition in women with a history of recurrent pregnancy loss are different, compared with those in normal fertile women.

Detailed description

The investigators want to describe the endometrial microbiome composition in normal fertile women and women with a history of recurrent pregnancy loss by analyzing mid-luteal phase vaginal swab and endometrial biopsy samples using 16S rRNA sequencing.

Conditions

• Recurrent Pregnancy Loss, Not Pregnant
• Vaginal Microbiome

Interventions

Type	Name	Description
OTHER	Vaginal swab and endometrial biopsy	A vaginal swab (DNA/RNA shield collection tube with swab - Zymo Research, CatNo R1107) and endometrial biopsy (Endobrush® - Lab CCD, Paris, France) will be obtained during 18th - 22nd day of the menstrual cycle.

Timeline

• Start date: 2022-12-12
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2022-08-22
• Last updated: 2025-09-25

Locations

2 sites across 1 country: Vietnam