NCT05507476

Nasal Desmopressin Versus Topical Epinephrine in Endonasal Dacryocystorhinostomy

Effects of Nasal Desmopressin Spray Versus Topical Epinephrine on Surgical Field Clarity and Hemodynamics in Endonasal Dacryocystorhinostomy: a Randomized Clinical Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Dacryocystorhinostomy aims to create a channel between the lacrimal sac and nasal mucosa to relieve nasolacrimal duct occlusion. General anesthesia is still preferred by many surgeons to secure the airway and control blood pressure.

Detailed description

Bleeding even minor can obscure the surgical field. This can extend the operative time \& increase the failure rate. The hemostatic effect of desmopressin on the quality of the surgical field was investigated in patients undergoing endoscopic sinus surgery and revealed that desmopressin could reduce intraoperative bleeding.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray	The patient will receive two puffs of desmopressin acetate 10 µg/puff in the side of the nasal cavity ipsilateral to the obstructed lacrimal duct (20 μg totally) 60 minutes before surgery.
DRUG	Epinephrine topical 1:100,000 Nasal Packs	The patient will receive topical 1:100,000 epinephrine in the side of the nasal cavity ipsilateral to the obstructed lacrimal gland via 3 soaked packs placed in the middle meatus for 5 minutes immediately before the start of surgery.

Timeline

• Start date: 2022-09-01
• Primary completion: 2023-06-01
• Completion: 2023-06-01
• First posted: 2022-08-19
• Last updated: 2024-10-01

Locations

1 site across 1 country: Egypt