NCT05507398

The Anti-tumor Effect of Metformin And Atorvastatin in Breast Cancer

Comparative Clinical Study Evaluating the Anti-tumor Effect of Metformin Versus Atorvastatin as an Adjuvant Therapy With Chemotherapy in Patients With Non-metastatic Breast Cancer

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims at evaluating and comparing the anti-tumor effects of metformin and statins (hydroxyl-methyl-glutaryl-CoA reductase inhibitors) in patients with non-metastatic breast cancer (stage I, II, \& III).

Detailed description

Worldwide, BC is the most frequently diagnosed life-threatening cancer in women. In EGYPT, breast cancer is the foremost oncologic problem, contributing to 20% of all cancers and 43% of female cancers. Metformin and atorvastatin have anti-tumor effects. To date, there are limited data to investigate and compare the anti-tumor effect between metformin and statins in patients with breast cancer.

Conditions

• Breast Cancer Female

Interventions

Type	Name	Description
DRUG	Placebo, metformin and atorvastatin	comparing the anti-tumor effects of metformin and atorvastatin

Timeline

• Start date: 2022-10-01
• Primary completion: 2023-07-01
• Completion: 2023-09-01
• First posted: 2022-08-19
• Last updated: 2022-10-31