NCT05506085

Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 12 (estimated)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia as part of their clinical care. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional magnetic resonance imaging (fMRI). While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as magnetic resonance imaging (MRI).

Conditions

• Laryngeal Dystonia
• Adductor Spastic Dysphonia of Dystonia

Interventions

Type	Name	Description
DEVICE	Deep Brain Stimulation	Deep Brain Stimulation of Globus Pallidus interna

Timeline

• Start date: 2022-10-01
• Primary completion: 2030-08-01
• Completion: 2030-08-01
• First posted: 2022-08-18
• Last updated: 2025-07-17

Locations

1 site across 1 country: United States