Trials / Completed
CompletedNCT05505682
Impact of Project Wolbachia - Singapore on Dengue Incidence
Assessing the Efficacy of Male Wolbachia-infected Mosquito Deployments to Reduce Dengue Incidence in Singapore: a Cluster Randomized Controlled Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 724,428 (actual)
- Sponsor
- National Environment Agency, Singapore · Other Government
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The study is a cluster-randomised controlled trial set in Singapore, to assess if the deployment of male Wolbachia-infected Aedes aegypti mosquitoes can reduce dengue incidence in intervention clusters.
Detailed description
The study is designed as a parallel, two-arm, non-blinded cluster-randomised controlled trial to be conducted in high-rise public housing estates in Singapore. The aim is to determine whether large-scale deployment of male Wolbachia-infected Ae. aegypti mosquitoes can significantly reduce dengue incidence in intervention clusters. The investigators will use the cluster-randomised design, with the study area comprising 15 clusters with a total area of 10.9 km2, covering approximately 722,000 residents in 1,700 apartment blocks. Eight clusters will be randomly selected to receive the intervention, while the other seven will serve as non-intervention clusters. Intervention efficacy will be estimated through two primary endpoints: (1) odds ratio of Wolbachia exposure distribution (i.e. probability of living in an intervention cluster) among laboratory-confirmed reported dengue cases compared to test-negative controls, and (2) laboratory-confirmed reported dengue counts normalized by population size in intervention versus non-intervention clusters.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Biological (Male Wolbachia-infected Aedes aegypti) | Releases of male Wolbachia-infected Aedes aegypti mosquitoes |
Timeline
- Start date
- 2022-07-28
- Primary completion
- 2024-09-13
- Completion
- 2024-09-13
- First posted
- 2022-08-18
- Last updated
- 2025-05-22
Locations
1 site across 1 country: Singapore
Source: ClinicalTrials.gov record NCT05505682. Inclusion in this directory is not an endorsement.