NCT05505396

Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury

Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury in the Intensive Care Unit - a Prospective, Observational Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 459 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome. Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.

Conditions

• Acute Brain Injury
• Hyperglycemia
• Hyperlactatemia

Interventions

Type	Name	Description
OTHER	Sampling of blood and cerebrospinal fluid	Blood HbA1c, insulin, C-peptide and IL-6 measured at admission. Glucose and lactate measured every 4 hours during intensive care stay. Daily sampling of CSV analysed for glucose and lactate in patients with EVD.

Timeline

• Start date: 2022-10-24
• Primary completion: 2024-04-30
• Completion: 2024-10-30
• First posted: 2022-08-17
• Last updated: 2025-07-29

Locations

1 site across 1 country: Denmark