NCT05503212

Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral Artery Occlusions

Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral : the BRAVO Retrospective Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 682 (actual)
• Sponsor: Centre Hospitalier Universitaire Vaudois · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO. In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.

Conditions

• Ischemic Stroke
• Vertebral Artery Ischemia
• Arterial Occlusive Diseases
• Vertebrobasilar Insufficiency

Interventions

Type	Name	Description
OTHER	Conservative treatment (CT)	Best medical treatment without intravenous thrombolysis nor endovascular thrombectomy
OTHER	Intravenous thrombolysis (IVT)	Best medical treatment with intravenous thrombolysis but without endovascular thrombectomy
OTHER	Endovascular thrombectomy (EVT) ± intravenous thrombolysis (IVT)	Best medical treatment with endovascular thrombectomy with or without intravenous thrombolysis

Timeline

• Start date: 2003-01-01
• Primary completion: 2023-08-09
• Completion: 2023-08-09
• First posted: 2022-08-16
• Last updated: 2023-08-14

Locations

1 site across 1 country: Switzerland