NCT05502835

Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.

Detailed description

All Patients will be assigned randomly by using computerized program to one of the two equal groups. Patients will be (forty five patients per group): Group A ;( control group) Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 6 ml/kg/hr. Ringer's solution. Group B; Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation. Intraoperative fluid volume, hemodynamics, serum lactate and intestinal edema will be measured after induction of anesthesia and every hour till the end of the operation, length of the hospital stay, first time to gastrointestinal motion and postoperative complications are recorded.

Conditions

• Intraoperative Fluid Volume
• Hemodynamics
• Serum Lactate
• Intestinal Edema
• Length of the Hospital Stay
• First Time to Gastrointestinal Motion
• Postoperative Complications

Interventions

Type	Name	Description
DEVICE	pulse pressure variation	Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.
OTHER	conventional fluid management	Infusion of 6 ml/kg/hr. Ringer's solution.

Timeline

• Start date: 2022-08-20
• Primary completion: 2023-01-20
• Completion: 2023-01-25
• First posted: 2022-08-16
• Last updated: 2023-01-30

Locations

1 site across 1 country: Egypt