NCT05501093

Diabetes Reversal and the Subgingival Microbiota

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 102 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: —

Summary

This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples collected at each study visit include blood, plaque, and other oral samples. At the last study visit there is an optional dental cleaning.

Conditions

• Diabetes type2
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
OTHER	sample collection	Blood, plaque, and other oral samples

Timeline

• Start date: 2019-03-11
• Primary completion: 2025-06-30
• Completion: 2025-06-30
• First posted: 2022-08-15
• Last updated: 2026-03-19

Locations

2 sites across 1 country: United States