NCT05498090

Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (estimated)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: Male
• Age: 15 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will learn more about how the body uses energy. Usually, the body uses sugars as energy first and then fats are used when the sugar stores are gone. Some people have trouble using fats as energy. This can lead to feeling tired, difficulty exercising, and storing too much fat where it does not belong (like in the muscle). It is believed that some boys and men with Klinefelter Syndrome may not be able to use fats as energy normally, and that a medication called fenofibrate could help this.

Conditions

• Klinefelter Syndrome

Interventions

Type	Name	Description
DRUG	Fenofibrate 145 mg	Fenofibrate 145 mg PO daily for 4 weeks

Timeline

• Start date: 2022-11-03
• Primary completion: 2025-06-30
• Completion: 2025-08-30
• First posted: 2022-08-11
• Last updated: 2024-10-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study