NCT05496400

Anemia of Prematurity and Hemodynamics

Effect of Anemia of Prematurity and Its Treatment on Hemodynamics of Preterm Infants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: Marwa Mohamed Farag · Academic / Other
• Sex: All
• Age: 3 Weeks – 6 Weeks
• Healthy volunteers: Accepted

Summary

The aim of this work to study the hemodynamic changes accompanying anemia of prematurity in neonates with gestational age ≤32 weeks and the effect of its treatment on hemodynamics.

Detailed description

This prospective observational study aims to evaluate the hemodynamic changes provoked by anemia of prematurity and transfusion of packed red blood cells (RBCs). Nonanemic inpatient premature infants (Hematocrit\>30%) will be compared with pretransfusional anemic inpatient premature infants. Anemic premature infants will be assessed before and 24 hours after the transfusion of pRBCs. Cerebral, intestinal and renal blood flow velocities, cardiac output parameters will be measured in premature neonates who will fulfill the eligibility criteria of the study.This study will be conducted at the neonatal intensive care units in Alexandria University Hospitals.

Conditions

• Premature

Interventions

Type	Name	Description
RADIATION	Echocardiographic and Doppler studies	Echographic and Doppler studies will be performed using machine: model GE Vivid iq premium,WUXI,China and we will measure: 1. Cardiac output: 2. Cerebral, intestinal and renal blood flow velocities:

Timeline

• Start date: 2021-07-01
• Primary completion: 2022-02-01
• Completion: 2022-08-01
• First posted: 2022-08-11
• Last updated: 2022-08-12

Locations

1 site across 1 country: Egypt