NCT05494216

Advanced Sperm Selection Techniques and Their Contribution to Blastocyst Euploidy Rates

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 515 (actual)
• Sponsor: Ganin Fertility Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Comparing different advanced sperm selection techniques like Physiological ICSI (PICSI) and magnetic activated cell sorting (MACS) in terms of the PGT-A outcomes of each arm blastocysts

Detailed description

Advanced sperm selection methods like PICSI and MACS have been developed for selecting a healthy mature non apoptotic sperm with lower Sperm DNA fragmentation. Previous studies compared the pre-implantation embryo development parameters of those techniques, but none looked at comparing the PGT-A results or euploidy rates of the blastocysts derived from each sperm selection. PGT-A cases will be randomized on the day of ICSI to the 2 assigned sperm selection techniques.

Conditions

• Sperm DNA Fragmentation
• Infertility

Interventions

Type	Name	Description
OTHER	PICSI	Sperm selection using PICSI dish for selecting sperm with lower DNA fragmentation index
OTHER	MACS	Sperm selection using MACS for selecting sperm with lower DNA fragmentation index

Timeline

• Start date: 2022-08-01
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2022-08-09
• Last updated: 2024-05-07

Locations

1 site across 1 country: Egypt