NCT05491967

Comparison of Vascular Risk in Patients Treated for Obstructive Sleep Apnea/Hypopnea Syndrome

Comparison of Vascular Risk in Patients Treated for Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS) With Continuous Positive Airway Pressure (CPAP) and Mandibular Advancement Orthosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 172 (actual)
• Sponsor: Centre Hospitalier de Valence · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

a monocentric,non interventional, prospective study to compare cardiovascular risk in patients with Obstructive Sleep Apnea/Hypopnea Syndrome treated with Continuous Positive Airway Pressure (CPAP) and Mandibular Advancement Orthosis.

Detailed description

The first-line treatment of severe Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS) is nocturnal ventilation with Continuous Positive Airway Pressure (CPAP). and The second-line treatment is the mandibular advancement orthosis (MAO)\]. CPAP is the most effective treatment to reduce the apnea-hypopnea index (AHI). However, its tolerance is sometimes difficult, causing many discontinuations. The purpose of this review is to evaluate a vascular morbimortality criteria: * Cardiovascular: myocardial infarction, heart failure, rhythm disorder * Neurological: transient or non transient stroke * ophthalmologic: anterior ischemic optic neuropathy, occlusion of the central artery or central retinal vein occlusion

Conditions

• Obstructive Sleep Apnea/Hypopnea Syndrome

Timeline

• Start date: 2021-03-16
• Primary completion: 2022-03-16
• Completion: 2023-03-16
• First posted: 2022-08-08
• Last updated: 2025-09-08

Locations

1 site across 1 country: France