NCT05488236

Nuclear Magnetic Resonance for Embryo Ploidy Selection

Embryo Ploidy Selection by Nuclear Magnetic Resonance: a Fast, Low Cost and Non-invasive Technique to Increase the Success Rate of ART

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Instituto Valenciano de Infertilidade de Lisboa · Network
• Sex: Female
• Age: 18 Years – 48 Years
• Healthy volunteers: Accepted

Summary

This study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance embryo selection and the success rate of assisted reproductive technologies.

Detailed description

Assisted reproductive technologies (ART) refers to treatments used to assist people in achieving a pregnancy. Over the last years, ART have been developed with efforts to deliver a healthy baby. However, the selection of the embryo that most likely results in pregnancy remains a critical step in ART. Currently, this selection is based on morphological assessment of the embryos, but up to 70% of those embryos display an abnormal number of chromosomes. Preimplantation genetic test for aneuploidy (PGT-A) is used to assess the ploidy of embryos, although this is an invasive, expensive and time consuming technique. Alternatively, in order to predict the ploidy of pre-implantation embryos (euploidy vs aneuploidy), we suggest to characterise the metabolic profile of the embryo culture medium by Nuclear Magnetic Resonance (NMR), which is a non-invasive, low cost and fast technique. The aim of this study is to assess whether, using multivariable analysis to all the collected NMR data, it is possible to identify a differential metabolic pattern between aneuploid and euploid embryos which could improve embryo selection.

Conditions

• Aneuploidy
• Infertility

Interventions

Type	Name	Description
OTHER	Nuclear magnetic resonance analysis of embryo culture medium	Analysis of culture medium from euploid and aneuploid embryos by magnetic nuclear resonance.

Timeline

• Start date: 2021-04-07
• Primary completion: 2023-06-07
• Completion: 2023-06-07
• First posted: 2022-08-04
• Last updated: 2026-04-13

Locations

1 site across 1 country: Portugal