NCT05487183

Test Retest Reliability of OA and OH

Test Retest Reliability of Offset Analgesia and Onset Hyperalgesia Paradigm

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to measure the test retest reliability of offset analgesia (OA) and onset hyperalgesia (OH) across multiple study visits. OA and OH are quantitative sensory tests (QST) thought to measure how the brain modulates pain. This study will use a heat thermode to induce OA and OH in healthy, pain-free volunteers across 3 study visits. Additional QST measures and survey data relevant to pain modulation will be collected. This study lays the foundation required to use OA and OH as tools to measure pain modulation in clinical trials. Following their validation, we anticipate that OA and OH will serve as predictive and therapeutic biomarkers, which will aid both in the development of novel analgesics and in treatment selection leading to the personalization of pain management.

Conditions

• Analgesia
• Pain Catastrophizing
• Pain

Interventions

Type	Name	Description
BEHAVIORAL	Medoc cutaneous probe	A computer-controlled probe delivers temperatures to the skin to measure pain, OA, and OH
BEHAVIORAL	Quantitative sensory testing	Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain
BEHAVIORAL	Computer tasks	QST and computer tasks are used to measure changes in pain intensity

Timeline

• Start date: 2022-08-05
• Primary completion: 2024-04-10
• Completion: 2024-04-10
• First posted: 2022-08-04
• Last updated: 2024-06-20

Locations

1 site across 1 country: United States