NCT05482737

Clinical Impact of Red Cell Storage Age

Clinical Impact of Red Cell Storage Age: Individual Patient Data Meta-Analysis of Four Recent Large Randomized Trials

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 33,000 (actual)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The recent four RCTs evaluating effects of RBC storage age on morbidity and mortality found no statistically significant adverse effects of longer stored RBC compared to shorter storage ages. Unfortunately, none of these RCTs had sufficient numbers of subjects receiving RBC at either storage age extreme to identify consequences of RBC transfusion at these limits. To better investigate effects of RBC storage age on clinical outcomes, this study will perform secondary meta-analyses of merged common patient data elements -individual patient data (IPD) meta-analysis (IPDMA) - from the nearly 33,000 subjects enrolled in the four RCTs.

Conditions

• RBC Transfusions

Interventions

Type	Name	Description
OTHER	no intervention	This is an observational retrospective study (meta-analysis)

Timeline

• Start date: 2019-07-01
• Primary completion: 2023-08-01
• Completion: 2024-08-30
• First posted: 2022-08-01
• Last updated: 2024-10-03

Locations

1 site across 1 country: United States