NCT05482256

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

The Role of Detergents in the Pathogenesis of Eosinophilic Esophagitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Conditions

• Eosinophilic Esophagitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Esophageal String Test (EST)	Non-invasive, FDA-registered sampling method to evaluate eosinophilic inflammation in the esophagus. The EST is performed by having an individual swallow a capsule attached to a string which captures secretions from the esophagus. The end of the string is taped to the cheek and the capsule is swallowed with water. After 1 hour, the EST will be removed, and the string will be processed for laboratory analysis.
OTHER	Colgate	2 grams of toothpaste (pea sized amount) for 2 minutes
DIAGNOSTIC_TEST	High Resolution Esophageal Manometry (HREM)	Thin flexible tube with sensors placed in the nose and swallowed for esophagus placement to conduct reading regarding the lining of the esophagus taken for approximately 10 minutes

Timeline

• Start date: 2022-09-12
• Primary completion: 2023-02-10
• Completion: 2023-02-10
• First posted: 2022-08-01
• Last updated: 2025-10-24

Locations

1 site across 1 country: United States