Trials / Completed
CompletedNCT05481788
External Evaluation of Vancomycin Population Pharmacokinetic Models
External Evaluation of Vancomycin Population Pharmacokinetic Models and Development of Continuous Infusion Dosing Recommendations
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 300 (actual)
- Sponsor
- University Hospital, Brest · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded. Seven pharmacokinetic models' predictive performance will be evaluated on this database. Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.
Detailed description
Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.
Conditions
Timeline
- Start date
- 2021-04-16
- Primary completion
- 2021-10-01
- Completion
- 2021-11-01
- First posted
- 2022-08-01
- Last updated
- 2022-08-01
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT05481788. Inclusion in this directory is not an endorsement.